Second generation engineering of transketolase for polar aromatic aldehyde substrates
نویسندگان
چکیده
منابع مشابه
Second generation engineering of transketolase for polar aromatic aldehyde substrates.
Transketolase has significant industrial potential for the asymmetric synthesis of carboncarbon bonds with new chiral centres. Variants evolved on propanal were found previously with nascent activity on polar aromatic aldehydes 3-formylbenzoic acid (3-FBA), 4-formylbenzoic acid (4-FBA), and 3-hydroxybenzaldehyde (3-HBA), suggesting a potential novel route to analogues of chloramphenicol. Here w...
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ژورنال
عنوان ژورنال: Enzyme and Microbial Technology
سال: 2015
ISSN: 0141-0229
DOI: 10.1016/j.enzmictec.2015.01.008